JICDRO is a UGC approved journal (Journal no. 63927)
ORIGINAL RESEARCH
Year : 2015  |  Volume : 7  |  Issue : 1  |  Page : 18-23

Single nucleotide polymorphisms at interleukin (IL)-1β + 3954 and vitamin D receptor (VDR) TaqI in chronic periodontitis patients: A pilot study in North Indian population


1 Department of Periodontology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
2 Department of Biotechnology, Bundelkhand University, Jhansi, Uttar Pradesh, India
3 Professor, Periodontology, Career Dental College, Lucknow, Uttar Pradesh, India
4 Department of Periodontology, Faculty of Dental Sciences, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India
5 Department of Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Anika Daing
Department of Periodontology, Jamia Millia Islamia, New Delhi - 110 025
India
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Source of Support: This work was supported by the CSIR, network project NWP0034. This bears communication number 170/2011/SKR of CDRI., Conflict of Interest: None


DOI: 10.4103/2231-0754.153490

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Background: Increasing evidences support the role of genetic factors in susceptibility to chronic periodontitis. The aim of the present pilot study was to explore the association of two potential single nucleotide polymorphisms (SNPs): Interleukin (IL)-1β + 3954 (rs1143634, C > T) and vitamin D receptor (VDR) TaqI (rs731236, T > C) with chronic periodontitis in a North Indian population. Materials and Methods: Twenty-eight chronic periodontitis subjects and 47 periodontally healthy controls were recruited. Individual samples of venous blood were obtained from each subject. Genotyping was done by polymerase chain reaction, followed by restriction fragment length polymorphism (PCR-RFLP). Logistic regression and chi square test were used for genetic association analysis and a P value less than 0.05 taken as statistical significance. Statistical Analysis Used: Chi square test and odds ratio (OR) was used. Results: Genotypes and alleles of SNP IL-1β + 3954 did not show a significant association (P > 0.05) with chronic periodontitis. Genotype CC and allele C of VDR TaqI were significantly associated with a higher risk for chronic periodontitis as compared to subjects with TT genotype (CC/TT OR = 4.615; 95% confidence interval [CI]: 1.17 to 18.078 P = 0.028) and allele T (C/T OR = 2.423; 95% CI: 1.179 to 4.980). Conclusion: In North Indian population, genotype CC and allele C of VDR TaqI were associated with risk of chronic periodontitis. No significant correlation was found for IL-1β + 3954 polymorphism and chronic periodontitis.


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