JICDRO is a UGC approved journal (Journal no. 63927)
Year : 2014  |  Volume : 6  |  Issue : 2  |  Page : 118-125

Peripheral giant cell granuloma: A comprehensive review of an ambiguous lesion

1 Department of Periodontics and Oral Implantology, Dr. D.Y. Patil Dental College and Hospital, Pune, Maharashtra, India
2 Department of Oral and Maxillofacial Pathology and Microbiology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India

Correspondence Address:
Ketki P Kalele
Department of Oral and Maxillofacial Pathology and Microbiology, V.Y.W.S. Dental College and Hospital, Amravati - 444 607, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-0754.143501

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Peripheral giant cell granuloma (PGCG) is a non-neoplastic, tumor-like reactive lesion occurring exclusively on gingiva/alveolar crest. It is thought to arise from the periodontal ligament or the periosteum. Clinically, it bears resemblance to pyogenic granuloma, peripheral ossifying fibroma and many other peripheral lesions seen in the oral cavity, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, but still carries a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells and its treatment. The entity further holds significance because of its notorious behavior and its high tendency to recur. The present paper describes recurrent PGCG with a comprehensive insight of the literature on its etiology, clinical, radiological, histological, ultrastructural and molecular aspects. Special attention is given on the histogenesis of cells and their types as also on the differential diagnosis and treatment of this lesion.

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